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wget https://repo.open.catalyst.harvard.edu/nexus/content/groups/public/net/shrine/shrine-setup/2.0.0/shrine-setup-3.0.0-dist.zip -O shrine-setup.zip
unzip shrine-setup.zip

In that directory find two three database update scripts for your brand of database: adapterAuditDB-update-brand.sql and shrine_query_history-update-mysql.sql . Run each of the appropriate scripts on your databases. For MariaDB run the following:

mysql -u shrine -pdemouser adapterAuditDB < shrine-setup/adapter/sql/adapterAuditDB-update-mysql.sql
mysql -u shrine -pdemouser shrine_query_history < shrine-setup/adapter/sql/shrine_query_history-update-mysql.sql

mysql -u shrine -pdemouser qepAuditDB < shrine-setup/adapter/sql/qepAuditDB-update-mysql.sql

For MS SQL and Oracle, run the scripts appropriate for your databases. 

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Increase the number of connections to mariadb from the default 151 to at minimum 2049. In /etc/my.cnf add a max_connnections value.

[mysqld_safe]
max_connections = 20