The SHRINE adapter encountered an exception while attempting to use the I2B2 CRC.
There could be a myriad of reasons for this, most all of which fall under the domain of i2b2. It's possible that i2b2 itself is experiencing problems, or that the link between SHRINE and i2b2 (credentials or network connection) is faulty.
If you are a user or an admin, send the admin at the reporting adapter all the details about this problem.