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A unique feature of the eagle-i software is that the data collection and search tools are completely driven by ontologies. These ontologies are a set of modules that are written in the OWL language and edited and managed using Protégé. Beginning in 2009, the eagle-i Research Resource Ontology (ERO) was developed alongside the eagle-i applications to model various biomedical research resources such as instruments, Core Facilities, protocols, reagents, animal models and biospecimens. It has now been integrated into the VIVO-ISF Ontology, which leverages and expands upon both the eagle-i and VIVO ontologies to create a semantic framework that describes not only scientific resources but research activities and clinical activities.

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