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The local I2B2 PM cell could not be reached.
The most likely cause is that SHRINE is misconfigured, or that the PM ce= ll is malfunctioning.
If you are a user, supply all details of this error to your local site a= dmin.
If you are a site admin, check shrine.conf, ensure that the URL for the = PM cell is correct, ensure that i2b2 is responsive and reachable as configu= red.