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The functionality described in the user guide assumes that you have rece= ived the necessary prior authorizations to access a SHRINE network at your = institution. The process for this authorization varies according to your in= stitution and network.
Most SHRINE networks use a tool called the Data Steward Applicat= ion to request and approve query topics prior to use of the SHRINE Web Clie= nt. Your local administrator or network contact will provide information ab= out this prerequisite step, if applicable.
Details of shots presented in this document may vary from networ= k to network. Each network uses a different ontology and may be uniquely co= nfigured. We have attempted to note in this document where these situations= may be expected. If you have questions, please contact your local network = representative.
The default view on login is the Find Patients tab (1). Researcher= s will build and define their patient cohort by selecting and dropping medi= cal concepts (2) into inclusion and exclusion criteria panel (3). Onc= e defined, they can select various options before searching the network (4)= .
The Medical Concepts List consists of standardized medical billing domai= ns that include diagnosis, procedures, laboratory tests, medications and de= mographics information and visit details. There are over 2 million co= ncepts to select from. To help search and find the concept of choice,= this panel contains features to help locate a specific code.
A researcher can type the medical concept and view corresponding search = results (1), can select a filter to narrow down the domain of the search re= sults (2), or can browse the medical concept tree by manually opening and c= losing folders (3). Researchers can click on the info icon next to a = concept to view additional information for that concept.
Autosuggest List &nbs= p; &n= bsp; =  = ; Search Results with highlighted search criteria
=
2. Narrow search results with the filter = menu: The "Search" field defaults to search the entire medical concepts lis= t. A researcher can specify a specific domain or code set by selectin= g from the drop down list. The filter and search input field work in tandem= to help researchers find the concept of choice.
Filter by code domain or specific code ca= tegory
3. Browse the medical concept hierarchy.&= nbsp; A researcher can browse the medical concept panel by expanding and co= llapsing the folder and drill down to locate a folder or an individual conc= ept.
Click the concept to expand or collapse t= he folder.
The Inclusion and Exclusion Criteria panel is how researchers will defin=
e their patient population. After finding medical concept(s), simply =
drag and terms and drop it into the first group.
The f=
irst group will default to a green inclusion panel. Toggle to "withou=
t" to specify an exclusion panel or toggle to "when" to specify an event ba=
sed panel (1). Additional concepts added to this group will be =
related to one another by the OR operator (2). Specify a date range o=
r occurrence (3, 4, 5). Date ranges can start, end, or occur between =
selected dates (4). View the code within its relational hierarchy (6)=
. Delete an individual concept from a group (7) or delete an entire g=
roup (8). Additional groups will automatically appear below, connecti=
ng each group by the AND relational operator (9). Clear out the entir=
e panel with "Clear All" button (10).
Click the info icon next to a concept to = view its relational hierarchy
See examples of patient cohorts= at the end of this document.
The event based panel allows researchers to construct a patient cohort w= ith a sequence of events, where event A occurs before event B. To spe= cify an event based panel, toggle to select the "when" radio button (1).&nb= sp; The event panel contains 2 and only 2 events (2, 3). Each event m= ust contain at least 1 concept. A researcher can specify the time gap= between the two events (4, 5). An event based panel contains a clock= icon to signify that it is a sequence based panel (6).
See examples of event based pat= ient cohorts at the end of this document.
After defining the inclusion and exclusion panel, select or create a new= research topic (1), enter or autogenerate a name for this patient cohort (= 2), elect to include demographic distributions (3), and click "Count Patien= ts" to view results (4).
Select a previously created topic
New Research Topic window. Include the to= pic name (1), description (2), and click "Create" (3). Click the "x" icon t= o exit the window (4).
2. Name Field: In addition to the Researc= h Topic, the Name Field is required before searching the network. A researc= her can enter a name, or click the thunderbolt icon to have a name autogene= rate.
3. Demographic Distributions: Selecting t= his checkbox will include a graphical display of the patient cohort by dime= nsions of age, race, sex, and vital status. This will be visible on t= he View Results tab.
4. Count Patient button. When all require= d fields are complete, and errors are cleared out, the Count patient button= will become enabled.
Disabled button  = ; &nb= sp; &= nbsp; Enabled button
 = ;
The View Results tab (1) is divided into 2 main panels - The Previous Re= sults panel (2), and the View Patient Counts by Sites (3). The Edit C= riteria button seamlessly reloads the entire criteria set back into the Fin= d Patients tab (4).
Allows researcher to view the results of patient cohort criteria that ar= e currently in progress or have already completed. Each row contains = a status indicator (1), name, date/time stamp (2), and the ability to flag = a query (3), or edit the name (4). Default sorted by recent run date (= 2).
2. The default sort is by recent run date= . The previous results panel can also be sorted by status and name.
3. Flag a row to begin the process = of obtaining medical
4. Click the pencil icon to edit th= e name.
Select a row from Previous Results to load the results in the View Patie= nt Count by Sites panel. Information about the inclusion and exclusion crit= eria is displayed (1) including a readout of the criteria. A research= er can download a CSV file of the sites and corresponding counts (2). = Demographics Distributions, if selected, are collapsed by default (3).&nbs= p; Counts are default sorted in alphabetical order (4, 5), and can be sorte= d by site name (4) or status (5).
The Demographic Distributions section (1)= are a set of 4 graphs that display the patient cohort by dimensions o= f age, race, sex, and vital status (2). A researcher can download the= full set of results per site in a CSV format (3).